Executive Director, Oncology Discovery Chemistry, Oncology Targeted Discovery, Waltham Boston US

Oncology Research and Development (ORD) is a pivotal focus and growth platform at AstraZeneca. Our vision is to lead in the creation of a new generation of cancer therapies. We are committed to collaboration across all boundaries, driving innovation that makes a meaningful impact on the world by solving complex challenges.

As part of our continuous growth, we are investing in new capabilities and technologies to advance our industry-leading portfolio. Central to this effort is Oncology Targeted Discovery (OTD), a core discovery organization within ORD. OTD is key in developing transformational new medicines for clinical development, covering Small Molecules, Antibody Drug Conjugates (ADCs), and Radioconjugates (RCs).

As we embark on the next phase of our journey with a bold ambition to deliver at least 20 new medicines to patients by 2030, OTD will play a crucial role. It will drive scientific innovation to deliver the next wave of oncology medicines, helping to achieve our vision and improve patient outcomes globally.

Aligned to this ambition, we have created a new opportunity for an Executive Director, Oncology Discovery Chemistry based at our Waltham Massachusetts Site.  This is a pivotal senior leadership position within our growing oncology discovery chemistry organization and will have a critical role delivering the next wave of transformational oncology medicines.  Reporting to the Vice President, Global Oncology Chemistry & DMPK, you will have significant oversight of the discovery phase portfolio, covering all synthetic modalities and approaches but with a clear emphasis on leading and delivering our targeting chemistry strategy, including next generation Antibody Drug Conjugates (ADC) and Radioconjugates (RCs).  The role comes with significant portfolio responsibilities with accountability to execute and deliver our departmental scorecard objectives, particularly as they relate to targeted tumor delivery.  The position also comes with significant global line leadership responsibilities and as a senior leader within chemistry & DMPK, you will have an important role in coaching and developing the global chemistry talent base.  You will also be an integral part of the global chemistry & DMPK senior leadership team and will represent the department at the OTD portfolio committee and other governance meetings.  A key element to the role will be to lead our targeted chemistry strategy and build a portfolio of next generation ADCs and RCs, aligned to AstraZeneca’s aspiration to become a world leader in this key area of oncology drug discovery.  In addition, you will have an important role in helping to drive the strategic direction of the global department, harnessing the next generation of synthetic approaches to solve target tractability challenges.

Key responsibilities

Senior leader, accountable for leading a global discovery chemistry organization focused on the delivery of the ADC and RC oncology portfoliosAccountable for developing and executing the ADC and RC strategy including next generation linker-payload combinationsProvide insightful medicinal chemistry critique and portfolio oversight across the small molecule, ADC and RC oncology portfoliosProvide inspirational line leadership, helping to coach and develop the next generation of drug hunters across the global chemistry and DMPK organizationMember of the global chemistry & DMPK senior leadership team, contributing to the operational management of the broader department (budgets, hiring, portfolio resourcing, communications, health & safety) as well as helping to shape our culture globallyContribute to the strategic direction of the department including establishing novel small-molecule / synthetic platforms and applying these to future oncology projectsMaintain a high degree of understanding and awareness of key internal and external developments relevant to the design and optimization of next generation targeted approaches (ADCs, RC and SM drug conjugates)Work collaboratively with key expert partner functions across discovery and early development (e.g. discovery & pharmaceutical sciences) to drive scientific excellence, prioritize resources and focus activities to maximize portfolio accelerationRepresent the function at relevant governance meetings including the Oncology Research Board, providing expert scientific input and critique to support project delivery/prioritizationProvide scientific leadership across the department to inspire innovation, maintain the highest levels of scientific rigor and drive organizational performanceWork with leading academic institutions, external partners and collaborators to develop business critical science and platforms aligned to our strategic goalsMaintain and enhance the scientific reputation of the department through high impact publications, presentations at key scientific symposia and building strategic external relationships

Essential Requirements

PhD or equivalent degree in chemistry and at least 15 years relevant experience as a medicinal chemistExperience developing ADCs and other drug targeting approaches.Proven track record of portfolio delivery and advancing projects through all phases of the drug discovery processProven people leadership skills and experience leading significant sized medicinal chemistry groups / departments.Executive level communication skills with ability to work closely with partners across the enterprise and build relationships with senior stakeholders

Desirable Skills

Expert in drug design concepts and contemporaneous knowledge of novel approaches and modalities relevant to small molecule & ADC drug discoveryExcellent cross-functional knowledge and expert knowledge of the drug discovery process from target selection through to the nomination of a clinical drug candidate and transition into early developmentStrategically aware and able to identify, develop & apply new technologies and capabilities across the function and wider enterpriseExperience coaching and developing key talentIndustry-wide reputation with a significant body of peer-reviewed publications & presentationsAwareness of the competitive landscape across oncology

Date Posted

07-May-2025

Closing Date

09-Jul-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.